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G.3 Allosteric Modulation and Receptor Dimerization Emerging research suggests that the GLP-1 receptor does not function in isolation on the cell surface but rather forms functional complexes (dimers or higher-order oligomers) with other receptors that modulate its signaling properties: GLP-1R/GIPR heterodimers: In cell systems co-expressing GLP-1R and GIPR, the two receptors form heterodimeric complexes with distinct signaling properties compared to either homodimer
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