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Eight IgGs of the 13 binders are antagonists in GLP-1 R mediated cAMP signaling The 13 IgG binders were next assessed for their functional activity in the cAMP signaling pathway by using GLP-1 R-over-expressing CHO-K1 cells purchased from DiscoverX that are designed and validated for assessing GLP-1 R-induced cAMP signaling
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Heart disease is sometimes described as a “silent” condition because often there are no symptoms until a heart attack, or a stroke, occurs
