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The FDA-approved prescribing information for semaglutide products (Ozempic, Wegovy, and Rybelsus) does not list nephrolithiasis (kidney stones) as a recognized adverse effect, and large-scale randomized controlled trials, including the SUSTAIN and STEP trial programs, have not identified kidney stones as a significant safety signal associated with semaglutide therapy
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Both native GLP-1 and its analogs, including liraglutide and exenatide, exhibit similar inhibitory effects on platelet activation formation and thrombus
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